2-(Oxolan-2-yl)acetic acid → HCID 178520301, compound

Participants

Reaction Steps

The title compound, white solid (85 mg, 77%), MS (ISP) m/z=443.5 [(M+H)+], mp 181.5° C., was prepared in accordance with the general method of example 32 from trans-4-{2-[4-(2,3-dihydrofuro[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexanamine trihydrochloride (intermediate C) (110 mg, 0.25 mmol) and rac-(tetrahydro-furan-2-yl)-acetic acid.

Provenance & Evidence