2-[(2R)-oxolan-2-yl]acetic acid → HCID 178520759, compound

Participants

Reaction Steps

The title compound, white solid (87 mg, 79%), MS (ISP) m/z=443.5 [(M+H)+], mp 183° C., was prepared in accordance with the general method of example 32 from trans-4-{2-[4-(2,3-dihydrofuro[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexanamine trihydrochloride (intermediate C) (110 mg, 0.25 mmol) and (R)-(tetrahydro-furan-2-yl)-acetic acid.

Provenance & Evidence