HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2-Difluorocyclopropane-1-carboxylic acid → HCID 178523691, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2-Difluorocyclopropane-1-carboxylic acid | HCID 2782823 | — |
| Reactant | HCID 178478589 | HCID 178478589 | — |
| Product | HCID 178523691 | HCID 178523691 | — |
Reaction Steps
The title compound, white solid (92 mg, 85%), MS (ISP) m/z=435.4 [(M+H)+], mp 184.5° C., was prepared in accordance with the general method of example 32 from trans-4-{2-[4-(2,3-dihydrofuro[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexanamine trihydrochloride (intermediate C) (110 mg, 0.25 mmol) and 2,2-difluorocyclopropane-carboxylic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586579B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-562f0221430b43f1a6e37e53ebb707dc |
| Source note | uspto-grants-2013_11 |