Formic Acid → HCID 178523689, compound

HRID 2042475Notes

Reaction equation

HRID 2042475 reaction equation
Cl.Cl.Cl.[O:4]1[C:12]2[CH:11]=[CH:10][N:9]=[C:8]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[CH2:6][CH2:5]1.[CH:28](O)=[O:29]>>[O:4]1[C:12]2[CH:11]=[CH:10][N:9]=[C:8]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][CH:28]=[O:29])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 284Formic AcidHCID 178478589HCID 178478589, compound2×

Product 1

HCID 178523689HCID 178523689, compound

Procedure

The title compound, off-white solid (17 mg, 30%), MS (ISP) m/z=359.4 [(M+H)+], mp 170.5° C., was prepared in accordance with the general method of example 32 from trans-4-{2-[4-(2,3-dihydrofuro[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexanamine trihydrochloride (intermediate C) (70.4 mg, 0.16 mmol) and formic acid.

Sources & evidence

ORD record
ord-5cf22c1a8cd94fc7ac4ef169fc5c5ce8
Source dataset
uspto-grants-2013_11
Patent number
US08586579B2

Reaction notes

Loading…