反应详情

The title compound, white solid (72 mg, 77%), MS (ISP) m/z=471.5 [(M+H)+], mp 207° C., was prepared in accordance with the general method of example 32 from trans-4-{2-[4-(2,3-dihydrofuro[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexanamine trihydrochloride (intermediate C) (88 mg, 0.2 mmol) and (R)-4,4,4-trifluoro-3-hydroxybutanoic acid.