Acetic Acid → HCID 178474984, compound

HRID 2042487Notes

Reaction equation

HRID 2042487 reaction equation
Cl.Cl.Cl.[CH3:4][C:5]1[N:10]=[C:9]([N:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C@H:19]3[CH2:24][CH2:23][C@H:22]([NH2:25])[CH2:21][CH2:20]3)[CH2:13][CH2:12]2)[C:8]2[CH:26]=[CH:27][O:28][C:7]=2[CH:6]=1.[C:29](O)(=[O:31])[CH3:30]>>[CH3:4][C:5]1[N:10]=[C:9]([N:11]2[CH2:12][CH2:13][N:14]([CH2:17][CH2:18][C@H:19]3[CH2:20][CH2:21][C@H:22]([NH:25][C:29](=[O:31])[CH3:30])[CH2:23][CH2:24]3)[CH2:15][CH2:16]2)[C:8]2[CH:26]=[CH:27][O:28][C:7]=2[CH:6]=1

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 178422388HCID 178422388, compound2×

Product 1

HCID 178474984HCID 178474984, compound

Procedure

The title compound, white solid (101 mg, 88%), MS (ISP) m/z=385.4 [(M+H)+], mp 207.5° C., was prepared in accordance with the general method of example 32 from trans-4-{2-[4-(6-methyl-furo[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexylamine trihydrochloride (intermediate D) (136 mg, 0.3 mmol) and acetic acid.

Sources & evidence

ORD record
ord-d3fc3af470664366b9d80c7ff7055de1
Source dataset
uspto-grants-2013_11
Patent number
US08586579B2

Reaction notes

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