Oxane-4-carboxylic acid → HCID 178422389, compound

Participants

Reaction Steps

The title compound, off-white solid (128 mg, 94%), MS (ISP) m/z=455.4 [(M+H)+], mp 219° C., was prepared in accordance with the general method of example 32 from trans-4-{2-[4-(6-methyl-furo[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexylamine trihydrochloride (intermediate D) (136 mg, 0.3 mmol) and tetrahydropyran-4-yl-carboxylic acid.

Provenance & Evidence