Oxane-4-carboxylic acid → HCID 178430613, compound

HRID 2042493Notes

Reaction equation

HRID 2042493 reaction equation
Cl.Cl.Cl.[CH3:4][C:5]1[C:6]2[O:28][CH:27]=[CH:26][C:7]=2[C:8]([N:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C@H:19]3[CH2:24][CH2:23][C@H:22]([NH2:25])[CH2:21][CH2:20]3)[CH2:13][CH2:12]2)=[N:9][CH:10]=1.[O:29]1[CH2:34][CH2:33][CH:32]([C:35](O)=[O:36])[CH2:31][CH2:30]1>>[CH3:4][C:5]1[C:6]2[O:28][CH:27]=[CH:26][C:7]=2[C:8]([N:11]2[CH2:12][CH2:13][N:14]([CH2:17][CH2:18][C@H:19]3[CH2:20][CH2:21][C@H:22]([NH:25][C:35]([CH:32]4[CH2:33][CH2:34][O:29][CH2:30][CH2:31]4)=[O:36])[CH2:23][CH2:24]3)[CH2:15][CH2:16]2)=[N:9][CH:10]=1

Participants

3

Reactant 2

HCID 219302Oxane-4-carboxylic acidHCID 178430611HCID 178430611, compound2×

Product 1

HCID 178430613HCID 178430613, compound

Procedure

The title compound, white solid (121 mg, 89%), MS (ISP) m/z=455.4 [(M+H)+], mp 228° C., was prepared in accordance with the general method of example 32 from trans-4-{2-[4-(7-methyl-furo[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexylamine trihydrochloride (intermediate F) (136 mg, 0.3 mmol) and tetrahydropyran-4-yl-carboxylic acid.

Sources & evidence

ORD record
ord-d6f96dd783614a2b96234b74062a4590
Source dataset
uspto-grants-2013_11
Patent number
US08586579B2

Reaction notes

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