3-Methoxypropionic acid → HCID 178495588, compound

HRID 2042495Notes

Reaction equation

HRID 2042495 reaction equation
Cl.Cl.Cl.[CH3:4][C:5]1[C:6]2[O:28][CH:27]=[CH:26][C:7]=2[C:8]([N:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C@H:19]3[CH2:24][CH2:23][C@H:22]([NH2:25])[CH2:21][CH2:20]3)[CH2:13][CH2:12]2)=[N:9][CH:10]=1.[CH3:29][O:30][CH2:31][CH2:32][C:33](O)=[O:34]>>[CH3:29][O:30][CH2:31][CH2:32][C:33]([NH:25][C@H:22]1[CH2:21][CH2:20][C@H:19]([CH2:18][CH2:17][N:14]2[CH2:13][CH2:12][N:11]([C:8]3[C:7]4[CH:26]=[CH:27][O:28][C:6]=4[C:5]([CH3:4])=[CH:10][N:9]=3)[CH2:16][CH2:15]2)[CH2:24][CH2:23]1)=[O:34]

Participants

3

Reactant 2

HCID 1344423-Methoxypropionic acidHCID 178430611HCID 178430611, compound2×

Product 1

HCID 178495588HCID 178495588, compound

Procedure

The title compound, white solid (79 mg, 61%), MS (ISP) m/z=429.4 [(M+H)+], mp 177° C., was prepared in accordance with the general method of example 32 from trans-4-{2-[4-(7-methyl-furo[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexylamine trihydrochloride (intermediate F) (136 mg, 0.3 mmol) and 3-methoxypropionic acid.

Sources & evidence

ORD record
ord-45bde827dcdb40f492046a8bafcbd434
Source dataset
uspto-grants-2013_11
Patent number
US08586579B2

Reaction notes

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