3,3,3-Trifluoro-2-hydroxypropanoic acid → HCID 178523716, compound

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Reaction Steps

The title compound, light yellow solid (80 mg, 70%), MS (ISP) m/z=457.4 [(M+H)+], mp 204° C., was prepared in accordance with the general method of example 32 from trans-4-{2-[4-(6-methyl-2,3-dihydro-furo[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexylamine trihydrochloride (intermediate E) (110 mg, 0.25 mmol) and (RS)-3,3,3-trifluoro-2-hydroxypropanoic acid.

Provenance & Evidence