4-(4-Methylpiperazin-1-yl)benzoic acid → HCID 178480697, compound

HRID 2042506Notes

Reaction equation

HRID 2042506 reaction equation
Cl.Cl.Cl.[O:4]1[C:12]2[CH:11]=[CH:10][N:9]=[C:8]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[CH2:6][CH2:5]1.[CH3:28][N:29]1[CH2:34][CH2:33][N:32]([C:35]2[CH:43]=[CH:42][C:38]([C:39](O)=[O:40])=[CH:37][CH:36]=2)[CH2:31][CH2:30]1>>[O:4]1[C:12]2[CH:11]=[CH:10][N:9]=[C:8]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][C:39](=[O:40])[C:38]5[CH:37]=[CH:36][C:35]([N:32]6[CH2:31][CH2:30][N:29]([CH3:28])[CH2:34][CH2:33]6)=[CH:43][CH:42]=5)[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 7365324-(4-Methylpiperazin-1-yl)benzoic acidHCID 178478589HCID 178478589, compound2×

Product 1

HCID 178480697HCID 178480697, compound

Procedure

The title compound, white solid (95 mg, 71%), MS (ISP) m/z=533.3 [(M+H)+], mp 236° C., was prepared in accordance with the general method of example 32 from trans-4-{2-[4-(2,3-dihydrofuro[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexanamine trihydrochloride (intermediate C) (110 mg, 0.25 mmol) and 4-(4-methyl-piperazin-1-yl)-benzoic acid.

Sources & evidence

ORD record
ord-88dd55ea56484a9a9142303936d0cbc3
Source dataset
uspto-grants-2013_11
Patent number
US08586579B2

Reaction notes

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