2-Hydroxyisobutyric acid → HCID 178459881, compound

Participants

Reaction Steps

The title compound, white solid (101 mg, 97%), MS (ISP) m/z=517.4 [(M+H)+], mp 201° C., was prepared in accordance with the general method of example 32 from trans-4-{2-[4-(2,3-dihydrofuro[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexanamine trihydrochloride (intermediate C) (110 mg, 0.25 mmol) and 2-hydroxy-2-methyl-propionic acid.

Provenance & Evidence