3-(5-Methyl-1,2,4-oxadiazol-3-yl)benzoic acid → HCID 178432503, compound

HRID 2042515Notes

Reaction equation

HRID 2042515 reaction equation
Cl.Cl.Cl.[O:4]1[C:12]2[CH:11]=[CH:10][N:9]=[C:8]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[CH2:6][CH2:5]1.[CH3:28][C:29]1[O:33][N:32]=[C:31]([C:34]2[CH:35]=[C:36]([CH:40]=[CH:41][CH:42]=2)[C:37](O)=[O:38])[N:30]=1>>[O:4]1[C:12]2[CH:11]=[CH:10][N:9]=[C:8]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][C:37](=[O:38])[C:36]5[CH:40]=[CH:41][CH:42]=[C:34]([C:31]6[N:30]=[C:29]([CH3:28])[O:33][N:32]=6)[CH:35]=5)[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 71278183-(5-Methyl-1,2,4-oxadiazol-3-yl)benzoic acidHCID 178478589HCID 178478589, compound2×

Product 1

HCID 178432503HCID 178432503, compound

Procedure

The title compound, white solid (125 mg, 97%), MS (ISP) m/z=517.4 [(M+H)+], mp 218° C., was prepared in accordance with the general method of example 32 from trans-4-{2-[4-(2,3-dihydrofuro[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexanamine trihydrochloride (intermediate C) (110 mg, 0.25 mmol) and 3-(5-methyl-[1,2,4]oxadiazol-3-yl)-benzoic acid.

Sources & evidence

ORD record
ord-42f089358af44eb0837781a0dbe413f1
Source dataset
uspto-grants-2013_11
Patent number
US08586579B2

Reaction notes

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