Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Isopropyl iodide | HCID 6362 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | HCID 12796524 | HCID 12796524 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 59651915 | HCID 59651915 | 65% |
Reaction Steps
A solution of the product from step 1 in 10 mL of DMF was added Cs2CO3 (2 eq. 1.95 g) and 2-iodopropane (1.2 eq., 360 uL). The reaction was heated to 80° C. for 2 h, and then filtered through celite, washed with MeOH:CH2Cl2 (95:5). The filtrate was concentrated and purified by silica gel flash chromatography (MeOH:CH2Cl2, 97:3) to afford 585 mg (65%) of the product: Mp 124-6° C.; MS m/z 301 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08586588B2 |
|---|
| Source dataset | uspto-grants-2013_11 |
|---|
| ORD ID | ord-14c00b20d72142849be11c16b736bad1 |
|---|
| Source note | uspto-grants-2013_11 |
|---|
