2-(3-Azabicyclo[3.1.0]hex-3-yl)-5-aminopyridine → N-[6-(3-Azabicyclo[3.1.0]hex-3-yl)-pyridin-3-yl]-5-fluoro-1-(3-fluorobenzyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide

HRID 204255Notes

Reaction equation

HRID 204255 reaction equation
[CH:22]12[CH2:23][N:24]([c:28]3[cH:29][cH:30][c:31]([NH2:34])[cH:32][n:33]3)[CH2:25][CH:26]1[CH2:27]2.[F:1][c:2]1[cH:3][c:4]2[c:5]([n:6][cH:7]1)[n:8]([CH2:14][c:15]1[cH:16][c:17]([F:21])[cH:18][cH:19][cH:20]1)[c:9]([C:11](=[O:12])[OH:13])[cH:10]2>>[F:1][c:2]1[cH:3][c:4]2[c:5]([n:6][cH:7]1)[n:8]([CH2:14][c:15]1[cH:16][c:17]([F:21])[cH:18][cH:19][cH:20]1)[c:9]([C:11](=[O:13])[NH:34][c:31]1[cH:30][cH:29][c:28]([N:24]3[CH2:23][CH:22]4[CH:26]([CH2:25]3)[CH2:27]4)[n:33][cH:32]1)[cH:10]2

Participants

3

Reactant 2

HCID 574315312-(3-Azabicyclo[3.1.0]hex-3-yl)-5-aminopyridineHCID 669079435-Fluoro-1-(3-fluorobenzyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid

Product 1

HCID 66908003N-[6-(3-Azabicyclo[3.1.0]hex-3-yl)-pyridin-3-yl]-5-fluoro-1-(3-fluorobenzyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide

Sources & evidence

ORD record
ord-e706ea1cbadd467b86e9634d512ea085
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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