HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2042555Generated: October 27, 2026
Methylhydrazine → 5-(4-methoxy-phenyl)-2-methyl-2H-pyridazin-3-one
https://huagongshe.com/reaction/2042555
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methylhydrazine | HCID 6061 | — |
| Reactant | 5-Hydroxy-4-(4-methoxy-phenyl)-5H-furan-2-one | HCID 59651978 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-(4-methoxy-phenyl)-2-methyl-2H-pyridazin-3-one | HCID 56946198 | 46% |
Reaction Steps
A suspension of 5-hydroxy-4-(4-methoxyphenyl)-5H-furan-2-one (2.06 g, 10 mmol) in 30 mL of ethanol was stirred as methylhydrazine (0.78 mL, 1.5 eq) was added dropwise. The reaction was heated to reflux at 85° C. for 2 h, then the solvent was reduced at reduced pressure to give a solid, which was collected and washed with cold EtOH to give 1.0 g (46%) of 5-(4-methoxy-phenyl)-2-methyl-2H-pyridazin-3-one: MS m/z 217 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08586588B2 |
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| Source dataset | uspto-grants-2013_11 |
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| ORD ID | ord-96249b385c9c4f3c8f41388759d4390c |
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| Source note | uspto-grants-2013_11 |
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