HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2042563Generated: October 26, 2026
Hydrazine hydrate (1:1) → 5-(4-Methoxyphenyl)pyridazin-3(2H)-one
https://huagongshe.com/reaction/2042563
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 5-Hydroxy-4-(4-methoxy-phenyl)-5H-furan-2-one | HCID 59651978 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-(4-Methoxyphenyl)pyridazin-3(2H)-one | HCID 13558916 | 87% |
Reaction Steps
A suspension of 5-hydroxy-4-(4-methoxyphenyl)-5H-furan-2-one (2.00 g, 9.7 mmol) in 15 mL of ethanol was stirred as hydrazine hydrate (0.97 g, 2.0 eq) was added in dropwise. The reaction was stirred at 85° C. overnight, and then the solvent was reduced. The solid was collected and washed with cold EtOH to give 1.7 g (87%) of 5-(4-methoxy-phenyl)-2H-pyridazin-3-one: MS m/z 203 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08586588B2 |
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| Source dataset | uspto-grants-2013_11 |
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| ORD ID | ord-67e52c80ce454f42926903c19223b218 |
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| Source note | uspto-grants-2013_11 |
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