Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-Fluoroethyl bromide | HCID 12982 | — |
| Reactant | 6-(4-Methoxyphenyl)-2,3-dihydropyridazin-3-one | HCID 2810166 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 59652003 | HCID 59652003 | 97.1% |
Reaction Steps
A mixture of 6-(4-methoxyphenyl)-2H-pyridazin-3-one (170 mg, 0.83 mmol), 1-bromo-2-fluoroethane (122.5 mg, 1.5 eq.), NaI (20 mg) and cesium carbonate (553 mg, 2.0 eq.) in 5 mL of CH3CN was heated to 70° C. overnight. The reaction mixture was filtered and concentrated. The product was purified by ISCO combiflash with 50% hexane and EtOAc to give 2-(2-fluoroethyl)-6-(4-methoxyphenyl)-2H-pyridazin-3-one (200 mg, 97%); MS m/z 349 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08586588B2 |
|---|
| Source dataset | uspto-grants-2013_11 |
|---|
| ORD ID | ord-791a1626afb84818afa0ff849f4b5283 |
|---|
| Source note | uspto-grants-2013_11 |
|---|
