1,4-Dioxane hydrochloride → HCID 59652021, compound

HRID 2042581Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH:26]=[CH:25][C:24](=[O:27])[NH:23][N:22]=3)=[CH:17][N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.O1CCOCC1>O1CCOCC1>[NH:8]1[CH2:9][CH2:10][CH:11]([O:14][C:15]2[N:16]=[CH:17][C:18]([C:21]3[CH:26]=[CH:25][C:24](=[O:27])[NH:23][N:22]=3)=[CH:19][CH:20]=2)[CH2:12][CH2:13]1

Participants

Conditions

Temperature: 60 °C

Procedure

To 4-[5-(6-oxo-1,6-dihydro-pyridazin-3-yl)-pyridin-2-yloxy]-piperidine-1-carboxylic acid tert-butyl ester (4.9 g, 13.2 mmol) in dioxane (30 mL) was added 4N HCl/dioxane (6.6 mL, 3 mmol). After overnight stirring at 60° C., the reaction was concentrated under vacuum to obtain 4 g of product as the HCl salt (quantitative); MS m/z 327 (M+H).

Workup

concentrationthe reaction was concentrated under vacuum

Sources & evidence

ORD record: ord-3c339361cb2d483eaf7ef0fe885a6087
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08586588B2

Reaction notes

Loading…