HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2042588Generated: November 3, 2026
Ethyl 3-(4-methoxybenzoyl)propionate → 4-(4-Hydroxyphenyl)-4-oxo-butyric acid ethyl ester
https://huagongshe.com/reaction/2042588
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl 3-(4-methoxybenzoyl)propionate | HCID 585132 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Product | 4-(4-Hydroxyphenyl)-4-oxo-butyric acid ethyl ester | HCID 11435990 | 99% |
Reaction Steps
To 4-(4-methoxy-phenyl)-4-oxo-butyric acid ethyl ester (4.5 g, 19.0 mmol) was added 48% HBr (50 mL). After overnight stirring at 120° C., the reaction was concentrated and ethanol was added several times and concentrated to obtain 4.18 g product (94%); MS m/z 223 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08586588B2 |
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| Source dataset | uspto-grants-2013_11 |
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| ORD ID | ord-605494865fdd47999234d57eead7d3e9 |
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| Source note | uspto-grants-2013_11 |
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