2-Hydrazinopyridine → HCID 24993503, compound

HRID 2042592Notes

Reaction equation

HRID 2042592 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([C:21](=O)[CH2:22][CH2:23][C:24]([OH:26])=O)=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[NH:28]([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=1)[NH2:29]>C(O)(=O)C>[NH:8]1[CH2:9][CH2:10][CH:11]([O:14][C:15]2[CH:16]=[CH:17][C:18]([C:21]3[CH2:22][CH2:23][C:24](=[O:26])[N:28]([C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=4)[N:29]=3)=[CH:19][CH:20]=2)[CH2:12][CH2:13]1

Participants

4

Reactant 2

HCID 786452-HydrazinopyridineHCID 67010115HCID 67010115, compound

Product 1

HCID 24993503HCID 24993503, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
120 °C

Procedure

To 4-[4-(3-carboxy-propionyl)-phenoxy]-piperidine-1-carboxylic acid tert-butyl ester (1.34 g, 3.55 mmol) in acetic acid (20 mL) was added 2-hydrazinopyridine (1.94 g, 17.8 mmol). After overnight stirring at 120° C., the reaction was concentrated under vacuum and the product was purified using a Single Step column (9:1 dichloromethane:methanol) to obtain 295 mg; MS m/z 351 (M+H).

Workup

  1. concentrationthe reaction was concentrated under vacuum
  2. customthe product was purified
  3. customto obtain 295 mg

Sources & evidence

ORD record
ord-a61d89e57aed46d7bdcc2e4e9f7e38a4
Source dataset
uspto-grants-2013_11
Patent number
US08586588B2

Reaction notes

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