3-Oxabicyclo(3.2.0)heptane-2,4-dione → 2-(4-Methoxy-benzoyl)-cyclobutanecarboxylic acid

Participants

Reaction Conditions

Reaction Steps

To 3-oxabicyclo[3.2.0]heptane-2,4-dione (8.00 g, 63.4 mmol) in THF (90.00 mL) at −78° C. was added 0.500 M of p-anisyl magnesium bromide (133 mL, 66.6 mmol) in THF (90 mL) dropwise. After stirring at −78° C. for 2 h, the reaction was quenched with ice cold water and concentrated. The aqueous layer was acidified and the white solid was filtered off and dried to obtain 9.72 g product (65%); MS m/z 233 (M−H).

Provenance & Evidence