HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 2-(4-Hydroxy-benzoyl)-cyclobutanecarboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | 2-(4-Methoxy-benzoyl)-cyclobutanecarboxylic acid | HCID 59651935 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-(4-Hydroxy-benzoyl)-cyclobutanecarboxylic acid ethyl ester | HCID 59651912 | — |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
To 2-(4-methoxy-benzoyl)-cyclobutanecarboxylic acid (10.28 g, 43.88 mmol) was added 48% hydrogen bromide in water (50 mL) and acetic acid (50 mL). After overnight stirring at 120° C., the reaction was concentrated, stirred with ethanol a few times, and the product was purified using a Single Step column (7:3 hexanes:ethyl acetate) to obtain 7.70 g (71%); MS m/z 247 (M−H)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586588B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-8c109f440d9b424a88c112f2d65b3f71 |
| Source note | uspto-grants-2013_11 |