indium(III)chloride → HCID 178515844, compound

HRID 2042746Notes

Reaction equation

HRID 2042746 reaction equation
[Cl-].[In+3].[Cl-].[Cl-].O1[C:9]2([CH2:14][CH2:13][CH:12]([C:15]3[CH:20]=[CH:19][C:18]([C:21]4[CH:25]=[C:24]([O:26][CH2:27][C:28]5[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=5[O:34][C:35]([F:38])([F:37])[F:36])[NH:23][N:22]=4)=[CH:17][N:16]=3)[CH2:11][CH2:10]2)[O:8]CC1>CO.O>[F:38][C:35]([F:36])([F:37])[O:34][C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=1[CH2:27][O:26][C:24]1[NH:23][N:22]=[C:21]([C:18]2[CH:19]=[CH:20][C:15]([CH:12]3[CH2:13][CH2:14][C:9](=[O:8])[CH2:10][CH2:11]3)=[N:16][CH:17]=2)[CH:25]=1

Participants

5

Reactant 2

HCID 159675indium(III)chlorideHCID 178506374HCID 178506374, compound

Product 1

HCID 178515844HCID 178515844, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolvent2×HCID 962WaterSolvent

Procedure

Indium chloride (0.11 g, 0.536 mmol) was added to a solution of Example 93E (0.255 g, 0.536 mmol) in methanol (3 ml) and water (3 mL). The resulting solution was heated (85° C.) for hours before the methanol was evaporated. The residue was partitioned with ethyl acetate and water, and the organic phase was washed with brine, dried (magnesium sulfate), filtered, and concentrated. The crude product was used in the following step without further purification.

Workup

  1. customwas evaporated
  2. customThe residue was partitioned with ethyl acetate and water
  3. washthe organic phase was washed with brine
  4. dry with materialdried (magnesium sulfate)
  5. filtrationfiltered
  6. concentrationconcentrated
  7. customThe crude product was used in the following step without further purification

Sources & evidence

ORD record
ord-7a77301a199146a69d2382662e21ab7c
Source dataset
uspto-grants-2013_11
Patent number
US08586594B2

Reaction notes

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