反应详情

A solution of 18.0 g (84.4 mmol) of 2,6-dichloronicotinic acid in 180 ml of a 70% solution of ethylamine in water is stirred at ambient temperature for 72 hours. The excess amine is then evaporated under reduced pressure and then a 10% aqueous acetic acid solution is added until the product precipitates. The beige solid is filtered off, rinsed with cold water and dried in an oven. 10.5 g of the expected product are obtained. Melting point: 158-160° C. Yield=62%.

1. customThe excess amine is then evaporated under reduced pressure
2. additiona 10% aqueous acetic acid solution is added until the product
3. customprecipitates
4. filtrationThe beige solid is filtered off
5. washrinsed with cold water
6. customdried in an oven