HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylethylamine → (S)-N-(8-Hydroxytetralin-2-yl)-N-propyl-N-[2-(2-thienyl)ethyl]amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylethylamine | HCID 11723 | — |
| Reactant | HCID 53252537 | HCID 53252537 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | (S)-N-(8-Hydroxytetralin-2-yl)-N-propyl-N-[2-(2-thienyl)ethyl]amine | HCID 53252575 | — |
Reaction Steps
Synthesis worked according to the preparation of A7-1 when using 76 mg (0.23 mmol) (S)—N-(8-methoxytetralin-2-yl)-N-propyl-N-[2-(2-thienyl)ethyl]amine ((S)-A5-1: R═OMe, Cy=2-thienyl). Flash chromatography was done using hexane/ethyl acetate 10/1 in the presence of 1% (v/v) of dimethylethylamine to achieve compound 1b.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586603B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-c96a32c47c0540b69f69bec5a80e23d9 |
| Source note | uspto-grants-2013_11 |