8-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine → HCID 67250622, compound

HRID 2042778Notes

Reaction equation

HRID 2042778 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[CH2:11][CH:10]([NH:13][CH2:14][CH2:15][CH3:16])[CH2:9][CH2:8]2.[N:17]1[N:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]2=[C:19]([CH2:26][C:27](O)=O)[CH:18]=1>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[CH2:11][CH:10]([N:13]([CH2:14][CH2:15][CH3:16])[CH2:27][CH2:26][C:19]1[CH:18]=[N:17][N:21]3[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=13)[CH2:9][CH2:8]2

Participants

3

Reactant 2

HCID 127414178-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amineHCID 14145809(Pyrazolo[1,5-a]pyridin-3-yl)acetic acid

Product 1

HCID 67250622HCID 67250622, compound

Procedure

Synthesis works according to the preparation of A4-1 or A4-4 when using N-(8-methoxytetralin-2-yl)-N-propylamine (A2-1: R═OMe) and 3-pyrazolo[1,5-a]pyridinyl acetic acid (A3-13: R═OMe, Cy=3-pyrazolo[1,5-a]pyridinyl) (synthesis according to literature: Gmeiner, P. Arch Pharm 1988, Vol 321, p 517) and subsequent reaction according to the synthesis of A5-1.

Workup

  1. customSynthesis
  2. customworks according to the preparation of A4-1 or A4-4 when
  3. customaccording to the synthesis of A5-1

Sources & evidence

ORD record
ord-b606be3c710947ff9bd08b4153588b7d
Source dataset
uspto-grants-2013_11
Patent number
US08586603B2

Reaction notes

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