HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2,4-Difluoro-3-nitrobenzonitrile | HCID 45790497 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | 3-Amino-2,4-difluoro-benzylamine | HCID 56839969 | — |
Reaction Steps
A mixture of 3-nitro-2,4-difluoro-benzonitrile (500 mg, 2.72 mmol), Pd/C (200 mg), conc. HCl (1.50 mL, 18.0 mmol) and MeOH (25 mL) is stirred at rt overnight under a hydrogen atmosphere (3.2 bar). The catalyst is removed by filtration, the filtrate is concentrated and evaporated twice from EtOH to give the sub-title compound as HCl salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586604B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-1061e6a7ea614460900417f33f145800 |
| Source note | uspto-grants-2013_11 |