HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pivaloyl chloride → N-(3-amino-2,4-difluoro-benzyl)-2,2-dimethyl-propionamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pivaloyl chloride | HCID 62493 | — |
| Reactant | 3-Amino-2,4-difluoro-benzylamine | HCID 56839969 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | Sodium Bicarbonate | HCID 516892 | — |
| Product | N-(3-amino-2,4-difluoro-benzyl)-2,2-dimethyl-propionamide | HCID 56839977 | — |
Reaction Steps
TEA (400 μL, 2.86 mmol) followed by pivaloyl chloride (60 μL, 0.52 mmol) are added to 3-aminomethyl-2,6-difluoro-aniline (120 mg as HCl salt) in THF (10 mL) and stirred at rt overnight. The reaction mixture is diluted with EtOAc and sat. NaHCO3-solution, the organic layer is washed with water and brine, dried and concentrated to give the sub-title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586604B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-f299a9ae0554492f8a42abdf166fb64c |
| Source note | uspto-grants-2013_11 |