HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate → N-(2,4-Dichloro-3-amino-benzyl)-1-trifluoromethyl-cyclopropane carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 1-(Trifluoromethyl)cyclopropane-1-carboxylic acid | HCID 2778306 | — |
| Reactant | 3-(Aminomethyl)-2,6-dichloroaniline | HCID 56839968 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-(2,4-Dichloro-3-amino-benzyl)-1-trifluoromethyl-cyclopropane carboxamide | HCID 56839976 | — |
Reaction Steps
The sub-title compound is prepared from 3-amino-2,4-dichloro-benzylamine (0.310 g, 1.01 mmol), 1-trifluoromethyl-cyclopropane carboxylic acid (0.17 g, 1.1 mmol), TBTU (0.39 g, 1.2 mmol) and TEA (0.71 mL) in DMF in analogy to example 3e.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586604B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-90593978cc2945f28d3a116c8cad63cb |
| Source note | uspto-grants-2013_11 |