Pyridine → N-(4-Bromo-phenyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-5-nitro-nicotinamide

Participants

Reaction Steps

(1-Chloro-2-methyl-propenyl)-dimethylamine (1.54 mL, 5.63 mmol) is added to 2-(2,2-difluoro-ethoxy)-6-methylamino-5-nitro-nicotinic acid (880 mg, 5.12 mmol) in DCM (15 mL) and THF (15 mL) and stirred at rt for 15 min. Pyridine (607 μL, 7.67 mmol) followed by 4-bromoaniline are added to the reaction mixture and it is stirred for 1 h at rt. The mixture is concentrated, diluted with water and filtered. The filtercake is washed with water and dried to give the sub-title compound.

Provenance & Evidence