HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(4-Bromo-phenyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-5-nitro-nicotinamide → 5-amino-N-(4-bromo-phenyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(4-Bromo-phenyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-5-nitro-nicotinamide | HCID 86664893 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-amino-N-(4-bromo-phenyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-nicotinamide | HCID 86664892 | — |
Reaction Steps
A mixture of N-(4-bromo-phenyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-5-nitro-nicotinamide (150 mg, 0.35 mmol), THF (10 mL) and Ra—Ni (15 mg) is stirred for 6 h at rt under a hydrogen atmosphere (3.0 bar). The catalyst is removed by filtration and the filtrate is concentrated to give the sub-title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586604B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-c009d939a2574362ae9ed5a9e4112676 |
| Source note | uspto-grants-2013_11 |