Nitric Acid → HCID 178523750, compound

HRID 2042828Notes

Reaction equation

HRID 2042828 reaction equation
[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([C:6]([NH:8][C@H:9]2[CH2:14][CH2:13][C@H:12]([C:15]([F:18])([F:17])[F:16])[CH2:11][CH2:10]2)=[O:7])=[C:4]([O:21][CH2:22][CH2:23][F:24])[N:3]=1.[N+:25]([O-])([OH:27])=[O:26].OS(O)(=O)=O>>[Cl:1][C:2]1[C:20]([N+:25]([O-:27])=[O:26])=[CH:19][C:5]([C:6]([NH:8][C@H:9]2[CH2:14][CH2:13][C@H:12]([C:15]([F:18])([F:17])[F:16])[CH2:11][CH2:10]2)=[O:7])=[C:4]([O:21][CH2:22][CH2:23][F:24])[N:3]=1

Participants

4

Reactant 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 178523748HCID 178523748, compound

Product 1

HCID 178523750HCID 178523750, compound

Procedure

The sub-title compound is prepared from 6-chloro-2-(2-fluoro-ethoxy)-N-(trans-4-trifluoromethyl-cyclohexyl)-nicotinamide (2.08 g, 5.64 mmol), HNO3 (5.5 mL) and conc. H2SO4 (16 mL) in analogy with method described in example 1c.

Sources & evidence

ORD record
ord-abfba8fdba214580a0a7217c3f075783
Source dataset
uspto-grants-2013_11
Patent number
US08586604B2

Reaction notes

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