化工社化工社 化学情報印刷レポート · 研究参考用
2,2-Difluoro-2-(fluorosulfonyl)acetic acid → HCID 178508984、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,2-Difluoro-2-(fluorosulfonyl)acetic acid | HCID 2737516 | — |
| 反応物 | HCID 178508983 | HCID 178508983 | — |
| 触媒 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | HCID 178508984 | HCID 178508984 | — |
反応手順
2,2-Difluoro-2-fluorosulfonylacetic acid (205 μl, 1.98 mmol) in MeCN (20 ml) is added via a syringe pump to a mixture of N-(trans-4-trifluoromethyl-cyclohexyl)-2-(2-hydroxy-ethoxy)-6-amino-5-nitro-nicotinamide (390 mg, 0.994 mmol) and CuI (94 mg, 0.49 mmol) in MeCN (40 ml) over 2.5 h at 55° C. It is stirred for additional 20 min, then the mixture is concentrated and purified via extensive chromatography.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08586604B2 |
| 出典データセット | uspto-grants-2013_11 |
| ORD ID | ord-b7a297a27a75435f822bd888c9a61d96 |
| 出典メモ | uspto-grants-2013_11 |