HCID 178508984, compound → HCID 178507780, compound

HRID 2042839Notes

Reaction equation

HRID 2042839 reaction equation
[F:1][C:2]([F:30])([F:29])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:28])[C:11]2[CH:16]=[C:15]([N+:17]([O-])=O)[C:14]([NH2:20])=[N:13][C:12]=2[O:21][CH2:22][CH2:23][O:24][CH:25]([F:27])[F:26])[CH2:5][CH2:4]1>[Ni].[H][H]>[F:29][C:2]([F:1])([F:30])[C@H:3]1[CH2:4][CH2:5][C@H:6]([NH:9][C:10](=[O:28])[C:11]2[CH:16]=[C:15]([NH2:17])[C:14]([NH2:20])=[N:13][C:12]=2[O:21][CH2:22][CH2:23][O:24][CH:25]([F:26])[F:27])[CH2:7][CH2:8]1

Participants

3

Reactant 1

HCID 178508984HCID 178508984, compound

Product 1

HCID 178507780HCID 178507780, compound

Reagents, catalysts & solvents 1

HCID 178506447HCID 178506447, compoundCatalyst

Procedure

The sub-title compound is prepared from N-(trans-4-trifluoromethyl-cyclohexyl)-2-(2-difluoromethoxy-ethoxy)-6-amino-5-nitro-nicotinamide (150 mg, 0.339 mmol), Ra—Ni/H2 (3 bar) in analogy to example 7b.

Sources & evidence

ORD record
ord-6afb448912bb4787b7a71771099fe444
Source dataset
uspto-grants-2013_11
Patent number
US08586604B2

Reaction notes

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