HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → HCID 178453058, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | (2,4-Dichloro-3-isothiocyanato-benzyl)-carbamic acid tert-butyl ester | HCID 56840196 | — |
| Reactant | HCID 178507778 | HCID 178507778 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 178453058 | HCID 178453058 | — |
Reaction Steps
The title compound is prepared from (2,4-dichloro-3-isothiocyanato-benzyl)-carbamic acid tert-butyl ester (3.15 g, 9.45 mmol), 5,6-diamino-2-(2,2-difluoro-ethoxy)-N-(trans-4-trifluoromethyl-cyclohexyl)-nicotinamide (3.60 g, 9.42 mmol), EDC (2.0 g, 10.4 mmol) in MeCN (40 ml) in analogy to example 5c.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586604B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-850bf7b459ef4fc2bfbfc633e0795ee7 |
| Source note | uspto-grants-2013_11 |