Sodium Hydroxide → HCID 86669315, compound

HRID 2042844Notes

Reaction equation

HRID 2042844 reaction equation
[Cl:1][C:2]1[C:15]([NH:16][C:17]2[NH:18][C:19]3[C:20]([N:34]=2)=[N:21][C:22]([O:29][CH2:30][CH:31]([F:33])[F:32])=[C:23]([C:25]([O:27]C)=[O:26])[CH:24]=3)=[C:14]([Cl:35])[CH:13]=[CH:12][C:3]=1[CH2:4][NH:5][C:6](=[O:11])[C:7]([CH3:10])([CH3:9])[CH3:8].[OH-].[Na+]>CO>[Cl:1][C:2]1[C:15]([NH:16][C:17]2[NH:18][C:19]3[C:20]([N:34]=2)=[N:21][C:22]([O:29][CH2:30][CH:31]([F:32])[F:33])=[C:23]([C:25]([OH:27])=[O:26])[CH:24]=3)=[C:14]([Cl:35])[CH:13]=[CH:12][C:3]=1[CH2:4][NH:5][C:6](=[O:11])[C:7]([CH3:10])([CH3:9])[CH3:8]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86669314HCID 86669314, compound

Product 1

HCID 86669315HCID 86669315, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of N-{2,4-dichloro-3-[6-methoxycarbonyl-5-(2,2-difluoro-ethoxy)-1H-imidazo[4,5-b]pyridin-2-ylamino]-benzyl)-2,2-dimethyl-propionamide (9.80 g, 12.0 mmol) and 1 N NaOH (40 ml) in MeOH (40 ml) is stirred overnight at rt and 45 min at reflux. Then the mixture is concentrated, acidified with 1 N aq. HCl-solution and the precipitate is filtered, dried and purified by HPLC.

Workup

  1. temperatureat reflux
  2. concentrationThen the mixture is concentrated
  3. filtrationthe precipitate is filtered
  4. customdried
  5. custompurified by HPLC

Sources & evidence

ORD record
ord-e148a3687cfd4b51982cf6d1c905141e
Source dataset
uspto-grants-2013_11
Patent number
US08586604B2

Reaction notes

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