HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropanemethanamine → HCID 86669316, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropanemethanamine | HCID 75646 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 86669315 | HCID 86669315 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86669316 | HCID 86669316 | — |
Reaction Steps
The title compound is prepared from N-{2,4-dichloro-3-[6-hydroxycarbonyl-5-(2,2-difluoro-ethoxy)-1H-imidazo[4,5-b]pyridin-2-ylamino]-benzyl)-2,2-dimethyl-propionamide (125 mg, 0.242 mmol), cyclopropylmethyl-amine (25 μl, 0.29 mmol), TBTU (80 mg, 0.25 mmol), TEA (150 μl) in DMF in analogy to example 12c.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586604B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-fa3ad83faf7447579c2c0457dff02a81 |
| Source note | uspto-grants-2013_11 |