Aniline → N-(2,6-difluoro-phenyl)-2-methyl-6-nitro-benzamide

HRID 2042868Notes

Reaction equation

HRID 2042868 reaction equation
[N+:1]([C:4]1[CH:12]=[CH:11][C:10](C)=[CH:9][C:5]=1[C:6]([OH:8])=O)([O-:3])=[O:2].F[C:15]1C=CC=C([N+]([O-])=O)C=1C(O)=O.[F:27][C:28]1[CH:34]=[CH:33][CH:32]=[C:31]([F:35])[C:29]=1[NH2:30].NC1C=CC=CC=1>>[F:27][C:28]1[CH:34]=[CH:33][CH:32]=[C:31]([F:35])[C:29]=1[NH:30][C:6](=[O:8])[C:5]1[C:4]([N+:1]([O-:3])=[O:2])=[CH:12][CH:11]=[CH:10][C:9]=1[CH3:15]

Participants

5

Reactant 4

HCID 6115AnilineHCID 183715-Methyl-2-nitrobenzoic acidHCID 796472,6-DifluoroanilineHCID 6037582-Fluoro-6-nitrobenzoic acid

Product 1

HCID 66664557N-(2,6-difluoro-phenyl)-2-methyl-6-nitro-benzamide

Procedure

Compound 118a was prepared following the preparation procedure described above with respect to compound 107, but 2-nitro-5-methylbenzoic acid was substituted for 2-fluoro-6-nitrobenzoic acid and 2,6-difluoroaniline was substituted for aniline.

Workup

  1. customthe preparation procedure

Sources & evidence

ORD record
ord-980808ba970848548f695840756dbfb4
Source dataset
uspto-grants-2013_11
Patent number
US08586597B2

Reaction notes

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