HCID 86683815, compound → HCID 178423951, compound

HRID 2042873Notes

Reaction equation

HRID 2042873 reaction equation
CC1C(=O)CC(N2CC3C(=CC=CC=3)N(CCNC3N=CN=C4C=3N=CN4COCC[Si](C)(C)C)C2)=C(C=1)[C:7]#[N:8].O[C:42]1[CH:43]=[C:44]([N:48]2[C:57](=[O:58])[C:56]3[C:51](=[CH:52][CH:53]=[CH:54][C:55]=3[CH3:59])[N:50]=[C:49]2[CH:60]([NH:62][C:63]2[N:71]=[CH:70][N:69]=[C:68]3[C:64]=2[N:65]=[CH:66][NH:67]3)[CH3:61])[CH:45]=[CH:46][CH:47]=1>>[CH3:59][C:55]1[CH:54]=[CH:53][CH:52]=[C:51]2[C:56]=1[C:57](=[O:58])[N:48]([C:44]1[CH:45]=[CH:46][CH:47]=[CH:42][C:43]=1[C:7]#[N:8])[C:49]([CH:60]([NH:62][C:63]1[N:71]=[CH:70][N:69]=[C:68]3[C:64]=1[N:65]=[CH:66][NH:67]3)[CH3:61])=[N:50]2

Participants

3

Reactant 2

HCID 86683815HCID 86683815, compoundHCID 1784239553-(3-hydroxy-phenyl)-5-methyl-2-[1-(9H-purin-6-ylamino)-ethyl]-3H-quinazolin-4-one

Product 1

HCID 178423951HCID 178423951, compound

Procedure

Compound 141 was treated with 4N HCL in NeOH for 1 hour using the procedure described for compound 121 (step B) to provide compound 140. m/z=423 (M+H). The structure of compound 140 is shown below.

Sources & evidence

ORD record
ord-95fd8e1070bb429f9329838a0254e840
Source dataset
uspto-grants-2013_11
Patent number
US08586597B2

Reaction notes

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