Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | HCID 68931300 | HCID 68931300 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 86623366 | HCID 86623366 | 45,707.699% |
Reaction Steps
Compound 0403-51 (264 mg, 0.624 mmol) was dissolved in hot anhydrous dioxane (8.6 mL). The solution was cooled to 40° C. and was treated with NEt3 (189 mg, 1.87 mmol) and MsCl (107 mg, 0.935 mmol) for 20 min. The mixture was concentrated and purified by column chromatography on silica gel (CH2Cl2/MeOH=50/1) to give the title compound 0404-51 as a white solid (143 g, 50%): LCMS: 501 [M+1]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08586605B2 |
|---|
| Source dataset | uspto-grants-2013_11 |
|---|
| ORD ID | ord-800600440d544578a3a170831527631c |
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| Source note | uspto-grants-2013_11 |
|---|
