反应详情

The mixture of cyanides 39 (105 g, 156 mmol, ca. 2:1 β:α) was slurried in ethanol (1 L) and heated to reflux with stirring. The reaction mixture was held at reflux for 1 h to ensure that all of solution had homogenized. It was then cooled evenly at 15° C./h to ambient temperature and stirred overnight at this temperature. The resulting solid was isolated by filtration and dried in vacuo to yield the titled compound β-39 (53 g, 51%) as a white solid.

1. temperatureheated
2. temperatureto reflux
3. temperatureat reflux for 1 h
4. stirringhad homogenized
5. temperatureIt was then cooled evenly at 15° C./h to ambient temperature
6. stirringstirred overnight at this temperature
7. customThe resulting solid was isolated by filtration
8. customdried in vacuo