5-Bromo-2-fluorobenzaldehyde → (5-Bromo-2-fluorophenyl)methanol

Participants

Reaction Steps

To a solution of 5-bromo-2-fluorobenzaldehyde (30.0 g, 148 mmol) in EtOH was added sodium borohydride (8.39 g, 222 mmol) at 0° C. The resulting mixture was stirred with gradual warming to ambient temperature over 15 h, re-cooled to 0° C., and quenched with aq. saturated NH4Cl solution. The mixture was extracted with EtOAc. The organic layer was washed with brine, dried over MgSO4, filtered and evaporated in vacuo to yield the titled compound (30.3 g, quantitative) as a white sold, which was carried on to the next step without further purification.

Provenance & Evidence