HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Hydroxy-2-naphthoic acid → 4-Bromo-1-hydroxynaphthalene-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Hydroxy-2-naphthoic acid | HCID 6844 | — |
| Reactant | Bromine | HCID 24408 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 4-Bromo-1-hydroxynaphthalene-2-carboxylic acid | HCID 289393 | 92.5% |
Reaction Steps
Bromine (6.1 mL, 120 mmol) was added to a solution of naphthoic acid 17 (18.9 g, 100 mmol) in glacial acetic acid (250 mL). The mixture was stirred at room temperature overnight. The resulting solid was filtered and dried in vacuo to provide the titled compound 18 (24.7 g, 92%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586550B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-41d693948ca74c9899da0024e5940776 |
| Source note | uspto-grants-2013_11 |