HCID 86680890, compound → HCID 67995547, compound

Participants

Reaction Steps

The bromide 58 (300 mg, 0.46 mmol) was added to a microwave reaction tube containing copper(I) cyanide (124 mg, 1.38 mmol) in NMP. The capped reaction tube was placed in a microwave reactor and the mixture irradiated at 230° C. for 30 min. After dilution with EtOAc, the organic layer was washed with 15% NH4OH solution prior to drying over anhydrous MgSO4. After filtration and concentration under reduced pressure, the residue was purified by silica column chromatography to provide the cyanide 59 (208 mg, 76%) as a white solid. MH+597.

Provenance & Evidence