Cesium carbonate → HCID 67995507, compound

Participants

Reaction Steps

The bromide 58 (300 mg, 0.46 mmol) was added to a microwave reaction tube containing cyclopropylboronic acid (86.9 mg, 1.01 mmol), palladium(II) acetate (31 mg, 46 μmol), tricyclohexylphosphonium tetrafluoroborate (68 mg, 0.18 mmol) and cesium carbonate (601 mg, 1.84 mmol) in dioxaone (5 mL). The capped reaction tube was placed in a microwave reactor and the mixture irradiated at 150° C. for 25 min. After dilution with EtOAc, the organic layer was washed with water and brine prior to drying over anhydrous MgSO4. After filtration and concentration under reduced pressure, the residue was purified by silica column chromatography to provide the cyclopropane 60 (56 mg, 20%) as a yellow oil. MH+612.

Provenance & Evidence