Sodium Methoxide → HCID 70650761, compound

Participants

Reaction Steps

To a solution of acetate 79 (195 mg, 0.32 mmol) in MeOH (15 mL) were added sodium methoxide (25 wt. % in MeOH, 1 mL) at room temperature. The mixture was stirred at room temperature for 1 hours. The amberlite IR-120H resin was added to the mixture to acidify the mixture. The mixture was filtered off and the filtrate was concentrated in vacuo. The residue was purified by prep HPLC (C18) to provide the titled compound 80 (25 mg, 18%).

Provenance & Evidence