Potassium Hydroxide → HCID 57616341, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of compound 84 (740 mg, 0.93 mmol) in a mixture of EtOH (20 mL) and THF (10 ml) was added KOH (250 mg). The reaction mixture was stirred at 50° C. for 1 d. After reaction complete, the resulting solution was quenched with 1.0 M HCl and organic layer was extracted with EtOAc. After evaporating volatile material under reduced pressure, the residue was purified with normal phase column chromatography to afford titled compound 85 (370 mg, 62%) as off-white solid.

Provenance & Evidence