Ammonium Chloride → HCID 67996207, compound

Participants

Reaction Steps

To the solution of aldehyde 101 (390 mg, 0.55 mmol) in THF (5.5 mL) was added methyl magnesiumbromide (3.0 M in ether, 0.28 mL) at 0° C. The reaction mixture was allowed to warm to room temperature and stirred for 3 h. The mixture was poured into a saturated NH4Cl solution and then extracted with CH2Cl2. The organic layer was dried over anhydrous MgSO4, filtered and concentrated in vacuo. Purification by silica gel column chromatography provided the desired secondary alcohol 103 (300 mg, 75%) as a solid. MH+723.

Provenance & Evidence