Ammonium Chloride → HCID 86680898, compound

Participants

Reaction Steps

To the solution of methyl ester 105 (350 mg, 0.47 mmol) in THF (2.5 mL) was added ethyl magnesiumchloride (1.2 mL, 2.0M solution in THF) and Ti(Oi-Pr)4 (0.15 mL 0.52 mmol) at 0° C. The reaction mixture was allowed to warm to room temperature and stirred for 18 h. The reaction mixture was poured into a saturated NH4Cl solution and extracted with ethyl acetate. The organic layer was dried over anhydrous MgSO4, filtere, and concentrated in vacuo. Purification by silica gel column chromatography provided of desired tertiary alcohol 107 (98 mg, 28%) as a solid. MH+734.

Provenance & Evidence